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Technicians

BAgr in Animal Science, South China Agricultural University (SCAU), 2025 My current research is focused on: Machine Learning; Embedded Systems (specifically ESP32); Large Language Model (LLM) Agent System Design Email：jianghanchn@vipqqcom

Design Agr Animal System Science

李文卓 2025-10-27 20:28:43

Postgraduate Students

BS Bioinformatics，Fujian Agriculture and Forestry University，2024 My current research is focused on ： Genome evolution Email: chenyajue2021@163com

evolution Genome Bioinformatics Fujian focused

李文卓 2025-10-26 20:38:04

Research Assistants

MS Biotechnological and Biomedicine Science, Sun Yat-sen University(SYSU),2025 BS Biological engineering,Hubei University(HUBU),2022 My current research is focused on : Enzyme engineering; Computational Chemistry Email:ayliu@siataccn

engineering University Email Chemistry Computational

李文卓 2025-10-26 20:33:10

轮播图

Automated engineering genome

系统管理员 2025-04-25 13:10:15

Research Assistants

MS Pharmacology, Jilin Agricultural University, 2019 BS Applied Biological Science, Jilin Agricultural University, 2015 Doubt is the key to knowledge Email：jzli2@siataccn

Jilin University Agricultural jz Email

系统管理员 2025-04-25 16:18:24

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琅琊

系统管理员 2025-04-25 13:39:23

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新闻全文详见《中国科学院之声》公众号https://mpweixinqqcom/s/sx0GbfnQ9V5ITe9Sm8LqqA 12月10日，中国科学院深圳先进技术研究院合成生物学研究所(以下简称“合成所”)司同课题组和南京大学化学化工学院的王欢课题组合作，在国际著名化学期刊Angewandte Chemie中发表了题为《Biosynthesis of Gut-Microbiota-Derived Lantibiotics Reveals a Subgroup of S8 Family Proteases for Class III Leader Removal》的文章。南京大学博士后章盈盈，合成所助理研究员洪志来、合成所博士后周亮（已出站）为论文共同第一作者，王欢教授和司同研究员为论文共同通讯作者。本工作首次报道了具有特异性识别位点的肽酶可以参与III型羊毛硫肽生物合成过程。在长期共同进化中，肠道菌群与宿主共同构成超级生物体，一起成长，一起变老，度过或长或短的一生。肠道菌群作为超级生物体不可分割的一部分，对宿主有着重要的影响，也因此被喻为“隐形的器官”，这一“器官”健康与否就取决于菌群的种类和结构。由于肠道是这个星球中微生物最为密集的地方之一，这些肠道菌面临着巨大的“内卷”压力。如何脱颖而出呢？有的训练宿主免疫系统躲过追杀（瞒天过海），有的通过转化宿主代谢物炼制毒药（借刀杀人）。但是，最有效的“卷”法还是要自己能打，通过苦练修习将武功外化为独门武器——抗生素，在必要时放倒或者杀死别的肠道菌。在之前的研究中，科学家发现包括人类在内的动物体内，肠道菌能产生丰富的抗生素武器，形成了血雨腥风的微生物江湖。江湖中不同门派流传着各自的独家武功秘籍，又叫生物合成基因簇（Biosynthetic Gene Cluster，BGC）。这些秘籍用ATCG四种字母记载，篇幅有长有短（通常为10-100kb，或者1万到10万字）。其中有一大门派，其武功秘籍篇幅较短（1万字左右）、容易习得，使用的武器叫做“翻译后修饰核糖体多肽（Ribosomally synthesized Post-translationally modified Peptide, RiPP）。由于RiPP发音和英文中排骨Rib的发音一致，因此江湖人称“排骨派”。排骨派声势浩大，分舵堂口众多，说来话长，今天着重讲一讲叫lanthipeptide的这一分舵，中文名叫羊毛硫肽。其名字来源与羊排是否有关，众说纷纭，已是谜案，按下不表；但通过研究动物肠道菌中羊毛硫肽分子及其生物合成过程，将有助于解析肠道菌间的相（ai）互（hen）作（qing）用（chou），进而理解菌群种类和结构如何影响宿主疾病和健康。该研究在模式动物大鼠肠道菌中发现了一类新颖的窄谱羊毛硫肽抗生素amylopeptins，解析了基因簇内S8家族丝氨酸肽酶AmyP如何参与前导肽移除和抗生素活性的激活。本工作首次报道了具有特异性识别位点的肽酶可以参与III型羊毛硫肽生物合成过程。南京大学博士后章盈盈，合成所助理研究员洪志来、合成所博士后周亮（已出站）为论文共同第一作者，王欢教授和司同研究员为论文共同通讯作者。在长期共同进化中，肠道菌群与宿主共同构成超级生物体，一起成长，一起变老，度过或长或短的一生。肠道菌群作为超级生物体不可分割的一部分，对宿主有着重要的影响，也因此被喻为“隐形的器官”，这一“器官”健康与否就取决于菌群的种类和结构。由于肠道是这个星球中微生物最为密集的地方之一，这些肠道菌面临着巨大的“内卷”压力。如何脱颖而出呢？有的训练宿主免疫系统躲过追杀（瞒天过海），有的通过转化宿主代谢物炼制毒药（借刀杀人）。但是，最有效的“卷”法还是要自己能打，通过苦练修习将武功外化为独门武器——抗生素，在必要时放倒或者杀死别的肠道菌。在之前的研究中，科学家发现包括人类在内的动物体内，肠道菌能产生丰富的抗生素武器，形成了血雨腥风的微生物江湖。江湖中不同门派流传着各自的独家武功秘籍，又叫生物合成基因簇（Biosynthetic Gene Cluster，BGC）。这些秘籍用ATCG四种字母记载，篇幅有长有短（通常为10-100kb，或者1万到10万字）。其中有一大门派，其武功秘籍篇幅较短（1万字左右）、容易习得，使用的武器叫做“翻译后修饰核糖体多肽（Ribosomally synthesized Post-translationally modified Peptide, RiPP）。由于RiPP发音和英文中排骨Rib的发音一致，因此江湖人称“排骨派”。排骨派声势浩大，分舵堂口众多，说来话长，今天着重讲一讲叫lanthipeptide的这一分舵，中文名叫羊毛硫肽。其名字来源与羊排是否有关，众说纷纭，已是谜案，按下不表；但通过研究动物肠道菌中羊毛硫肽分子及其生物合成过程，将有助于解析肠道菌间的相（ai）互（hen）作（qing）用（chou），进而理解菌群种类和结构如何影响宿主疾病和健康。新闻全文详见《中国科学院之声》公众号https://mpweixinqqcom/s/sx0GbfnQ9V5ITe9Sm8LqqA

肠道宿主 抗生素 菌群羊毛

系统管理员 2025-04-25 14:05:21

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Source:https://wwwnobelprizeorg/prizes/chemistry/2018/arnold/speech/ Frances H Arnold’s speech at the Nobel Banquet, 10 December 2018 Your Majesties, Your Royal Highnesses, Excellences, Dear Laureates, Ladies and gentlemen Let me start with a question: “Why did Newton’s apple fall to the ground?” First the answer from the physicist: “There is a force called gravity that exists between any two objects, with a magnitude proportional to the product of the objects’ masses, and inversely proportional to the square of the distance between the centers of the masses The apple is therefore propelled by this force towards the center of the earth when it leaves the tree” Now we will move to the answer from the evolutionary biologist: “Once upon a time, apples used to go in all directions, up, down, sideways – the world was full of ricocheting apples However, only those apples that fell to the ground were able to germinate and grow new trees Over millions of years, the forces of evolution selected for those apples which fell to the ground Which is why apples now fall to the ground” We are three chemists who shamelessly expropriate from physics and biology (including their terrible jokes) to create molecules for the common good We share deep admiration for evolution, a force of Nature that has led to the finest chemistry of all time, and to all living things on this planet The fuel for evolution is diversity, with natural selection leading to continuous adaptations and improvements in Nature’s handiwork Organisms (and organizations) without this diversity are doomed to extinction in a rapidly changing world Yet Nature has explored only a tiny fraction of the life and life’s molecules that are possible With evolution in our hands, with the ability to set genetic diversity and to tailor the forces of selection, we can now explore paths that Nature has left unexplored We can also explore paths that Nature will never explore: we can select living organisms and their chemistries for our benefit – to create new sources of energy, to fix the carbon in our atmosphere, to cure disease or to make us younger Or we can make new weapons of terror or of state control … which shall it be? The lesson from our apple joke: In practice and in theory, evolution is all too easy to apply incorrectly And so on behalf of all three laureates in Chemistry, whose recombined contributions evolved into tonight’s message, I propose a toast to evolution – may we use it well!

evolution Nature new apple The

系统管理员 2025-04-25 14:03:32

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I am excited to start my lab of engineering biology automation at SIAT in May 2019 I can be reached at tongsi (AT) siataccn Stay tuned!

May start siat Stay AT

系统管理员 2025-04-25 14:00:09

Research

Synthetic Tools Biology Automation

系统管理员 2025-04-25 13:12:05