李志成，研究员，博士生导师。国家重点研发计划首席科学家、科技部青年科学家，广东省级人才。医学成像科学与技术系统重点实验室研究员。聚焦脑肿瘤多尺度解析与诊疗应用研究，致力于以计算方法解决肿瘤生物医学问题、开拓肿瘤精准诊疗新途径。

围绕复杂异质性肿瘤的精准分型和诊疗应用问题，提出了影像-病理-基因融合解析理论和计算方法，绘制了脑胶质瘤多尺度全貌图谱，揭示了组织、细胞、分子跨尺度关联机制；发现了胶质瘤多尺度整合新亚型和新靶点，实现了胶质瘤分型-诊断-治疗-预后评估的全过程智能诊疗技术突破，为脑肿瘤开拓了多尺度融合诊疗新途径；研制了具有自主知识产权的时空谱高分辨活体结构-功能成像仪器，为肿瘤新机制规律发现和诊疗效果检验提供了科研工具。以一作和通讯作者发表论文60余篇，包括Nat Com, Radiology, IEEE系列汇刊等，含4篇ESI高被引、1篇入选2021中国脑胶质瘤研究进展。已授权发明专利20余项。主持国家重点研发计划项目-重大科学仪器专项、国自然联合基金重点项目、科技部863青年科学家、科学院B类先导专项课题、深圳市基础研究重点项目等科技计划12项。中科院青年创新促进会会员。研发的胶质瘤病理-分子整合分型和诊断技术已开展大规模临床评测，专利技术转移至国内头部企业。获中国图象图形学学会自然科学二等奖、吴文俊人工智能技术发明二等奖。担任European Radiology、Translational Oncology、Displays编委。担任中国图象图形学学会医学影像专委会秘书长。中国生物医学工程学会医学图像信息与控制分会委员。广东省医学会医学人工智能分会首届委员。深圳市医学会肿瘤影像和大数据分会副主委。

1. Qiuchang Sun#, Yinsheng Chen#, Chaofeng Liang, Yuanshen Zhao, Xiaofei Lv, Yan Zou, Kai Yan, Hairong Zheng, Dong Liang, Zhi-Cheng Li*. Biologic pathways underlying prognostic radiomics phenotypes from paired MRI and RNA sequencing in glioblastoma. Radiology. 301(3): 654-663, 2021.

2. Weiwei Wang#, Yuanshen Zhao#, Lianghong Teng#，Jing Yan#, Yang Guo, Yuning Qiu, Yuchen Ji, Bin Yu, Dongling Pei, Wenchao Duan, Minkai Wang, Li Wang, Jingxian Duan, Qiuchang Sun, Shengnan Wang, Huanli Duan, Chen Sun, Yu Guo, Lin Luo, Zhixuan Guo, Fangzhan Guan, Zilong Wang, Aoqi Xing, Zhongyi Liu, Hongyan Zhang, Li Cui, Lan Zhang, Guozhong Jiang, Dongming Yan, Xianzhi Liu, Hairong Zheng, Dong Liang, Wencai Li*, Zhi-Cheng Li*, Zhenyu Zhang*. Neuropathologist-level integrated classification of adult-type diffuse gliomas using deep learning from whole-slide pathological images. Nature Communications. 14: 6359. 2023.

3. Yuanshen Zhao#, Weiwei Wang#, Yuchen Ji, Yang Guo, Jingxian Duan, Xianzhi Liu, Dongming Yan, Dong Liang, Wencai Li, Zhenyu Zhang*, Zhi-Cheng Li*. Computational pathology for prediction of Isocitrate Dehydrogenase gene mutation from whole-slide images in adult patients with diffuse glioma. American Journal of Pathology. 194(5): 747-758. 2024.

4. Jingxian Duan#, Zhenyu Zhang#, Yinsheng Chen#, Yuanshen Zhao, Qiuchang Sun, Weiwei Wang, Hairong Zheng, Dong Liang, Jingliang Cheng*, Jing Yan*, Zhi-Cheng Li*. Imaging phenotypes from MRI for the prediction of glioma immune subtypes from RNA sequencing: a multicenter study. Molecular Oncology. 17(4): 629-646, 2023.

5. Jing Yan#, Yuanshen Zhao#, Yinsheng Chen#, Weiwei Wang, Wenchao Duan, Li Wang, Shenhai Zhang, Tianqing Ding, Lei Liu, Qiuchang Sun, Dongling Pei, Yunbo Zhan, Haibiao Zhao, Tao Sun, Chen Sun, Wenqing Wang, Zhen Li, Xuanke Hong, Xiangxiang Wang, Yu Guo, Wencai Li, Jingliang Cheng, Xianzhi Liu, Xiaofei Lv*, Zhi-Cheng Li*, Zhenyu Zhang*. Deep learning features from diffusion tensor imaging improve glioma stratification and identify risk groups with distinct molecular pathway activities. EBioMedicine. 72: 103583, 2021.